Camptothecin biosynthesis
WebThe hairy roots (HR) of Ophiorrhiza pumila produce camptothecin (CPT), a monoterpenoid indole alkaloid used as a precursor in the synthesis of chemotherapeutic drugs. O. pumila HR culture is considered as a promising alternative source of CPT, WebJul 1, 2024 · Camptothecin (CPT) has unique anti-tumor activities, and its analogs such as irinotecan and topotecan are clinically used as anti-cancer drugs. Recently, CPT biosynthesis pathway is gradually...
Camptothecin biosynthesis
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WebApr 12, 2024 · Flavonoids encompass a heterogeneous group of secondary metabolites with exceptional health benefits. Chrysin, a natural dihydroxyflavone, possesses numerous bioactive properties, such as anticancer, antioxidative, antidiabetic, anti-inflammatory, etc. However, using traditional sources of chrysin involves extracting honey from plants, … WebFeb 1, 2024 · The plant derived camptothecin (CPT) is a pentacyclic pyrroloquinoline alkaloid with unique antitumor activity. Successive discoveries of new CPT-producing plants occurred in recent years due to...
WebJan 1, 2013 · Camptothecin (1) is a well-known monoterpenoid indole alkaloid and was originally identified in the extracts of the Chinese tree Camptotheca acuminata (Nyssaceae) [ 3 ]. Camptothecin exhibits antitumor activity , which is due to its ability to kill cancer cells via topoisomerase I poisoning [ 4 ]. WebVery little is yet known definitively about camptothecin (2) biosynthesis. ... Institute in North Carolina; this was the same team that discovered taxol (now known as paclitaxel) …
WebApr 10, 2024 · The compound camptothecin showed hydrogen bond interaction with A:TYR73, A:ASN69, and A:SER60, while hydrophobic interaction with A:PHE67 (Fig. 1 B, Table 1 A). ... Management of melanin biosynthesis dehydratase inhibitor (MBI-D)-resistance in pyricularia oryzae using a non-MBI-D fungicidal application program for … WebJan 16, 2004 · Camptothecin derivatives are clinically used antitumor alkaloids that belong to monoterpenoid indole alkaloids. In this study, we investigated the biosynthetic …
WebJul 10, 2024 · Nothapodytes nimmoniana, a plant of pivotal medicinal significance is a source of potent anticancer monoterpene indole alkaloid (MIA) camptothecin (CPT). This compound owes its potency due to topoisomerase-I inhibitory activity. However, biosynthetic and regulatory aspects of CPT biosynthesis so far remain elusive. Production of CPT is …
WebInvestigations have shown that the glycerophospholipid PGP is a PTPMT1 target and regulates cardiac phospholipid biosynthesis and mitochondrial ... Qiu L, Li J, Ying K, Guo C, Zhang J. Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells. FEBS Lett. 2009; … razor commandsWebMar 24, 2024 · We used a combined omics approach to analyze the elicitation effects of MeJa, AgNO3, and PEG on camptothecin (CPT) biosynthesis in Camptotheca … razor comment blockWebApr 22, 2024 · VDOMDHTMLOCTYPE html> Identification of WRKY transcription factors involved in regulating the biosynthesis of the anti-cancer drug camptothecin in Ophiorrhiza pumila Horticulture Research Oxford Academic Abstract. Camptothecin is a chemotherapeutic drug widely used to treat various cancers. simpsons neds wifeWebApr 3, 2024 · Camptothecin (CPT) is a widely known monoterpene indole alkaloid with excellent anticancer activity. CPT has been isolated from different plant species. CPT- producing weedy plant O. pumila has brought about widespread attention, and the whole genome of O. pumila has been sequenced [ 29 ]. razor comms attach fileWebJan 6, 2024 · The actual and predicted yield of camptothecin by A. terreus was noticeably fluctuated from 10.5 to 170.5 μg/L, confirming the significance of the tested variables on camptothecin biosynthesis, and the efficiency of the Plackett–Burman design, the values of the coefficient of determination (R2 = 0.98) indicating the goodness-of-fit measure ... razor comic book characterWebMay 22, 2024 · Abstract. Camptothecin (CAM) is a well-known, complex, plant-derived antitumor monoterpenoid indole alkaloid (MIA). Featuring a unique pentacyclic … simpsons ned gets angryWebJun 22, 2016 · To unveil the CPT biosynthesis pathway, many efforts have been done for pathway gene identification and the application of large-scale RNA-sequencing technique accelerated screening of candidate genes which could be involved in CPT biosynthesis. razor comic book 10