WebApr 6, 2024 · [0031] 作为优选地实施方式,所述bone morphogenetic protein(bmp)信号通路抑制剂为ldn-193189; [0032] 优选地,所述wnt信号通路激活剂为chir99021; [0033] 优选地,所述shh信号通路激动剂为purmorphamine。 http://manu45.magtech.com.cn/Jwk_kqyxyj/CN/10.13701/j.cnki.kqyxyj.2024.12.019
肠道类器官培养基 MedChemExpress 培养基 干细胞 肠上皮 肠道
WebApr 11, 2024 · 应用2:细胞信号通路研究. 图3 检测不同浓度的HLY78系列衍生物对Wnt信号通路报告基因TOPflash的萤光素酶活性影响 . 通过检测不同浓度的HLY78系列衍生物对Wnt信号通路报告基因TOPflash的萤光素酶活性影响,筛选出HLY78和HLY119对Wnt信号通路有抑 … WebBiological Activity for CHIR 99021. CHIR 99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3) (IC 50 values … can rabbits eat hawkweed
[Joint regulation of Wnt and bone morphogenetic protein …
WebJul 18, 2024 · The small molecule CHIR99021 (C91) is a highly specific, safe, and most effective GSK-3β Inhibitor. This study found that it efficiently activates the canonical Wnt signaling of bone marrow … The discovery and application of small molecules is one of the practical strategies of safe osteogenic drugs. WebSep 6, 2024 · 肠道类器官培养基的关键成分包括 Wnt-3a (W)、表皮生长因子 (EGF) (E)、Noggin (N) 和 R-spondin-1 (R),统称为 WENR 培养基。. 在培养基中有序地添加这些生长因子可调控干细胞生态位信号通路 (包括 Wnt、骨形态发生蛋白 (BMP) 和 Notch 信号通路),诱导肠道干细胞 (ISCs) 自我 ... WebCHIR99021 promotes self-renewal of ESCs by modulating transforming growth factor β (TGF-β), Notch and mitogen-activated protein kinases (MAPK) signaling pathways. CHIR99021 is an agonist of wingless/integrated (wnt) signalling, upregulates cyclinA expression and promotes cell proliferation in non-small-cell lung cancer (NSCLC) cell lines. flanagan home times