Citron homology

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August undefined, 2024

WebJul 9, 2001 · Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo. Although hVam6p exhibits homology to the Saccharomyces cerevisiae vacuolar protein sorting gene product Vam6p/Vps39p, the presence of a citron homology (CNH) domain at the NH 2 terminus is unique to the … WebMar 2, 2024 · This protein is localized to the plasma membrane by means of the citron homology domain, where the middle region binds to CK2, thus preventing it from phosphorylating PTEN. This activated PTEN downregulates phosphatidylinositol (3,4,5)-trisphosphate, an important driving factor of AKT signaling. Reduced AKT signaling leads …

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WebNov 6, 1998 · Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. We have identified a novel … WebMay 26, 1998 · This region [“citron-homology” (CNH) domain] was identified as being homologous to the mouse Rho GTP /Rac GTP-binding protein, citron and to the C … flamethrowers in terraria

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WebApr 18, 2024 · Nous montrons ici que TNIK (Traf2 and Nck-interacting kinase) et xMINK (Misshapen/NIKs-related kinase) sont des composantes essentielles de ces deux voies de réponse. xTNIK et xMINK interagissent ensemble in vivo et subissent un clivage protéolytique libérant des domaines Kinase et Citron-NIK-Homology (CNH) … WebHomology more Human Ortholog CIT, citron rho-interacting serine/threonine kinase Vertebrate Orthologs 3 Human Diseases more Diseases 1 with human CIT associations Mutations, Alleles, and Phenotypes less Phenotype Summary 26 phenotypes from 2 alleles in 2 genetic backgrounds 24 phenotype references Phenotype Overview WebNov 15, 2011 · The predicted structure of Gek includes a serine/threonine kinase (STK) catalytic domain, a coiled-coil (CC) domain, a cysteine-rich region (CR), a pleckstrin homology (PH) domain, a citron homology (CH) domain and a Cdc42/Rac interactive binding (CRIB) domain (Luo et al., 1997) (supplementary material Fig. S1). flamethrowers in games

Citron homology

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WebAug 12, 2024 · Gene description. CNH domain-containing protein;Vacuolar protein sorting-associated protein 39 homolog. Primary source. … WebFeb 27, 2024 · C. elegans MRCK1 consists of an N-terminal CHB domain that mediates kinase domain dimerization, 28 followed by a region of predicted coiled-coil and C-terminal C1, pleckstrin homology (PH), and citron homology (CNH) domains of unknown structure and function (Figure 1 A). A Cdc42 and Rac-interactive binding (CRIB) motif is encoded …

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WebNov 3, 2010 · GCK proteins are characterized by an N-terminal kinase domain and a C-terminal citron homology (CNH) domain separated by a variable region of lower sequence homology (Dan et al., 2001). MINK and TNIK specifically bind to Rap2 via their CNH domains ( Taira et al., 2004 ; Nonaka et al., 2008 ). WebMost importantly, MRCKs, ROCKs, and CRIK contain a number of additional protein domains with distinct functions, including a small GTPase binding domain, a PH domain, a cysteine-rich domain, and a citron homology domain. It is this lack of motifs with known function that renders DMPK unique among its family members and in the AGC group as …

WebApr 16, 2004 · The CNH domain was originally found in citron that interacts with Rho and Rac . Subsequently, it was found in Rom2p, a GDP/GTP exchange factor for S. … WebJul 9, 2001 · Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo. Although hVam6p exhibits homology to the Saccharomyces cerevisiae vacuolar protein sorting gene product Vam6p/Vps39p, the presence of a citron homology (CNH) domain at the NH(2) terminus is unique to the …

WebMembers of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K4 is also called Nck Interacting kinase (NIK). It facilitates the activation of the MAPKs, extracellular signal-regulated kinase (ERK) 1, ERK2, and c-Jun N-terminal kinase (JNK), by phosphorylating and activating MEKK1. WebNational Center for Biotechnology Information

WebJun 11, 2024 · The Ser/Thr kinase MAP4K4, like other GCKIV kinases, has N-terminal kinase and C-terminal citron homology (CNH) domains. MAP4K4 can activate c-Jun N …

WebCitron homology (CNH) domain CRIB domain KELK-motif containing domain Myotonic dystrophy protein kinase, coiled coil PH-like domain superfamily Pleckstrin homology … can po box receive certified mailWebThe process of constructing SMART predicted (i) novel domain homologues in unexpected locations such as band 4.1-homologous domains in focal adhesion kinases; (ii) previously unknown domain families, including a citron-homology domain; (iii) putative functions of domain families after identification of additional family members, for example, a … can pocket knives be mailedWebMar 2, 2024 · This protein is localized to the plasma membrane by means of the citron homology domain, where the middle region binds to CK2, thus preventing it from … can podiatrists operateWebTreatment of mice with orally available HPK1 inhibitors results in increased activation of antigen- specific CD8+T cells in vivo and decreased tumor growth as single agent and in … can poc have straight hairWebMay 1, 2005 · Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a hematopoietic-specific mammalian STE20-like protein serine/threonine kinase, comprised of a STE20 … can poems have dialogueWebMar 2, 2024 · Another important region identified was the citron homology domain located at the end of the protein. Through fluorescent imaging, it was discovered that this domain … can poe injectors boost ip signalsWebJul 9, 2001 · Here, we report the identification of a novel human protein, hVam6p, that promotes lysosome clustering and fusion in vivo. Although hVam6p exhibits homology … flamethrowers in vietnam war