WebCTT meta-analysis of the effects of statins on muscle symptoms. Session: HOT LINE SESSION 9. Topic: Drug therapy. Speaker: Professor C. Baigent (Oxford, GB) Event: …
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WebAug 27, 2024 · The findings were based on an analysis of individual participant data included in 23 double-blinded statin therapy trials of at least 1,000 participants conducted … WebApr 10, 2024 · We conducted a meta-analysis on 19 of the 21 trials that reported data on all-cause mortality and 18 trials reporting data on MI and stroke. The ARR was 0.8% for all-cause mortality, 1.3% for MI, and 0.4% for stroke. ... another CTT analysis reported that the risk treating 10000 patients with statins for 5 years could result in 5 cases of ...
WebFeb 8, 2007 · Meta-analysis, which is mainly used in medical, social, and behavioral sciences, aims to pool results across independent studies in order to combine them in a … WebFeb 8, 2024 · “This risk reduction would be expected to be higher in high-risk patients.” As such, the CTT meta-analysis makes the case for statin therapy in at-risk individuals regardless of their age, provided the benefits outweigh the harms and the patient accepts long-term treatment, say Cheung and Lam. Potential For Real Gains in Older Patients
WebJan 31, 2024 · In 2008, a meta-analysis of individual patient data from 14 trials which included patients with DM was conducted by the CTT Collaboration to provide further information on the uncertainties which existed. 59 Among patients with DM, there was a 21% (P<0.0001) proportional reduction in major vascular events per 39 mg/dL LDL-C … WebNational Center for Biotechnology Information
WebMar 7, 2024 · Subgroup analysis. No heterogeneity in the efficacy of atorvastatin across major subgroups, including age, sex, ... (CTT) Collaborators, Kearney PM, Blackwell L, Collins R, Keech A, Simes J, et al. Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet. 2008;371(9607 ...
WebFeb 24, 2024 · Introduction. Statins reduce cardiovascular disease events in primary and secondary prevention, in men and women, and across all age groups. 1 2 Systematic reviews and meta-analyses of randomised trials have confirmed the safety of statins. 3 Although severe adverse effects are rare, statins increase the risk of myopathy (absolute … orden mantophasmatodeaWebJan 8, 2015 · We did a meta-analysis of studies included in the CTT Collaboration database reported up to 2010; the database includes trials of statin therapy versus control and trials that compared statin regimens of … iran wk selectieWebJun 4, 2012 · The CTT meta-analysis has many strengths but also a number of limitations, which have not been discussed and which, given the clinical implications, require … The concern for statin-induced hepatotoxicity leads to the underuse of … Review of current evidence and clinical recommendations on the effects of low … iran wk liveWebTrialists’ (CTT) meta-analysis that suggested a statin ‘‘event’’ benefit from maximal lowering of low-density lipoprotein cholesterol levels.2 There are two issues that deserve further attention: the components of the CTT study end points and, most importantly, the issue of reduction in all-cause mortality. orden leyes educativasWebAug 29, 2024 · An analysis of data from 23 trials within the Cholesterol Treatment Trialists’ (CTT) Collaboration, results of the study suggest the excess risk for muscle symptoms … iran women world cupWebApr 12, 2024 · Background: Bladder cancer (BCa) is the leading reason for death among genitourinary malignancies. RNA modifications in tumors closely link to the immune microenvironment. Our study aimed to propose a promising model associated with the “writer” enzymes of five primary RNA adenosine modifications (including m6A, m6Am, … orden mesitornithiformesWebJan 12, 2008 · We undertook a prospective meta-analysis to help resolve these uncertainties. Methods: Findings: During a mean follow-up of 4.3 years, there were 3247 major vascular events in people with diabetes. There was a 9% proportional reduction in all-cause mortality per mmol/L reduction in LDL cholesterol in participants with diabetes … iran wm team