Cystine starvation
WebAug 1, 2024 · Because SLC7A11-mediated cystine uptake promotes the biosynthesis of glutathione, an important antioxidant, we hypothesized that SLC7A11-high cancer cells should be less sensitive to glucose starvation (thus less dependent on glucose for survival), as these cells have better capabilities to detoxify glucose withdrawal–induced ROS. WebCystine uptake mediated by solute carrier family seven-member 11 (SLC7A11) inhibits ferroptosis but promotes cell death under glucose starvation [18, 19]. Recent studies have found that the ...
Cystine starvation
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WebMay 30, 2024 · Cysteine is required for maintaining cellular redox homeostasis in both normal and transformed cells. Deprivation of cysteine induces the iron-dependent form of cell death known as ferroptosis; however, the metabolic consequences of cysteine starvation beyond impairment of glutathione synthesis are uncharacterized. Here, we … WebApr 14, 2024 · 173.Copper starvation induces antimicrobial isocyanide integrated into two distinct biosynthetic pathways in fungi. 铜饥饿诱导抗菌剂异氰酸酯集成到真菌的两个不同的生物合成途径中。 174.Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes.
WebNov 1, 1999 · This study was designed to investigate changes in serum levels of lipid components and IGF-I during 7 d of starvation (no energy) in healthy young adults of both sexes and of normal weight, who were allowed a supervised 30-min walk twice a day. SUBJECTS AND METHODS Experimental subjects. WebIn the present study, we found that cystine starvation induces non- apoptotic cell death (Figures 1 and 2), and treatment with DFO, ferrostatin-1 ( Figure 1 H and Supplementary Figure 1) or ...
WebIntroduction. Ferroptosis is a newly identified type of iron-dependent programmed cell death that was first reported by Dixon et al in 2012. 1 As a new type of programmed cell death, ferroptosis is different from apoptosis, autophagy, necrosis, pyrolysis and other forms of cell death in terms of morphology and biochemistry. The morphological characteristics of …
WebAug 9, 2024 · Cystine starvation-induced GPX4 protein downregulation was mediated by protein translation suppression rather than reduction in mRNA transcription or protein stability. The authors reasoned that... small sectional ashley furnitureWebJun 11, 2024 · The cystine/glutamate antiporter SLC7A11 could transport cystine to promote the biosynthesis of GSH and maintain the redox balance, resulting in protection from ferroptotic cell death . However, SLC7A11 high cancer cells are highly dependent on glucose or glutamine for survival and are exquisitely sensitive to glucose or glutamine … highs 32 fulton mdWebDec 1, 2024 · underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis. Ferroptosis is an iron-dependent cell-death modality driven by aberrant accumulation of per- highs 38 lisbon mdWebOct 2, 2024 · Abstract. Ferroptosis belongs to a novel form of regulated cell death. It is characterized by iron dependence, destruction of intracellular redox balance and non … highs 36 annapolis mdWebMay 5, 2024 · Cysteine is a unique and highly reactive amino acid, which in addition to being used for the synthesis of coenzyme A (CoA), also generates glutathione that … highs 36WebSep 26, 2024 · The reference dietary intake (RDI) for cystine is 4.1mg per kilogram of body weight or 1.9mg per pound. A person weighing 70kg (~154 pounds) should consume 287mg of cystine per day. Below is a list of … highs 38WebAug 9, 2024 · The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synth … small sectional ashley