WebJun 1, 2014 · Cytoglobin (Cgb) was discovered in 2001 as a fourth member of the vertebrate globin family. It is also known as histoglobin or stellate cell activated protein (STAP), since it is expressed ubiquitously, and was identified in rat stellate cells in fibrotic liver tissue [1], [2]. WebMar 29, 2024 · Cytoglobin is a novel candidate tumour suppressor gene highly methylated in upper aero-digestive tract squamous cancer We now show that …
1V5H: Crystal Structure of Human Cytoglobin (Ferric Form) - RCSB
WebJun 1, 2010 · Cytoglobin (CYGB), a new member of the globin family, was discovered in 2001 as a protein associated with stellate cell activation (stellate cell activation-associated protein [STAP]). Knowledge... WebFeb 13, 2015 · Earlier kinetics studies on cytoglobin did not assign functional properties to specific structural forms. Here, we used defined monomeric and dimeric forms and cysteine mutants to show that an intramolecular disulfide bond (C38–C83) alters the dissociation rate constant of the intrinsic histidine (H81) (∼1000 fold), thus controlling binding of extrinsic … how many ounces is one serving of alcohol
Redox sensor properties of human cytoglobin ... - ScienceDirect
WebOct 21, 2014 · Cytoglobin is dynamically responsive to a number of insults, namely, fibrosis, oxidative stress, and hypoxia. Recently, it has been reported that Cygb is downregulated in a number of malignancies and that an induced overexpression reduces the proliferative characteristics of cancer cells. Cytoglobin is the protein product of CYGB, a human and mammalian gene. Cytoglobin is a globin molecule ubiquitously expressed in all tissues and most notably utilized in marine mammals. It was discovered in 2001 and named cytoglobin in 2002. It is thought to protect against hypoxia. The predicted function of … See more Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or reactive oxygen species, or serve a protective function during See more CYGB expression can be used as a specific marker with which hepatic stellate cells can be distinguished from portal myofibroblasts in … See more • cytoglobin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more • Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K (Jul 2001). "Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells" See more WebCytoglobin (Cgb) was discovered a decade ago and is a fourth member of the group of hexacoordinated globin-folded proteins. Although some crystal structures have been … how big is yugioh master duel