Echa read-across assessment framework
Webbe done via hazard and risk assessment. Grouping and read-across of NFs is a possible strategy to reduce resource consumption, maximising the use of existing data for assessment NFs. The GRACIOUS project provides a framework in which possible grouping and read-across for NFs is mainly based on an evaluation of their simi-larity. Webassessment elements have to be included in the read-across assessment to be accepted by ECHA. The RAAF, however, doesn’treflect the iterative process required to build a category/analogue approach. Read-Across: Step-by-Step The workflow of the read-across assessment comprises six main steps (Helman et al. 2024; Escher et al. 2024, …
Echa read-across assessment framework
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http://cefic-lri.org/wp-content/uploads/2014/03/ECHA-Cefic-LRI-Read-across-Workshop-Report_171211-FINAL.pdf WebThe third talk will describe application of the European Chemicals Agency (ECHA) Read-Across Assessment Framework (RAAF) to predict subchronic and developmental health effects for a target chemical. The fourth presentation will expand on the Presentation #3 case study to describe how broadening the use of read-across can help fill multiple data ...
WebInclude RAAF AE in the report – Read-Across Assessment Framework (RAAF) has been developed by ECHA as an internal tool providing a framework for a consistent and structured assessment of grouping and read across approaches under REACH. After selection of the appropriate RAAF scenario all corresponding assessment elements … WebThe ECHA Read-Across Assessment Framework (RAAF) structures the scientific evaluation of grouping and read-across approaches under REACH. The RAAF was …
WebRead-Across Assessment Framework (RAAF) Reference: ECHA-17-R-01-EN Cat. number: ED-02-17-140-EN-N ISBN: 978-92-9495-758-0 DoI: 10.2823/619212 ... Websubstances without having to test them all for each endpoint (‘read-across’). As a result, one gains efficiency and avoids animal testing. Grouping is used to fill in chemicals safety data in REACH registration dossiers and ... structural similarity is extensively described in existing ECHA Read Across Assessment Framework (RAAF) and
WebSep 1, 2024 · Methods: The workflow proposed by ECHA was used and slightly modified to present the read-across case study. The Read-Across Assessment Framework (RAAF) was used to evaluate the uncertainties of a ...
Webof chemicals (OECD, 2014) and ECHA Read-across Assessment Framework (ECHA, 2024). The key elements for read across which should be considered are: - Well defined endpoint, - Identity of the chemicals used in the read across process and assessment of the quality of the available experimental data, - Assessment of the similarity/dissimilarity ... caducidad zumo naranja naturalWebMar 31, 2024 · 1. Introduction. Read-across methodology is a commonly used tool for data gap filling in risk assessment [21], [59], [2], [100].The European Union Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) Regulation encourages use of read-across in an attempt to avoid unnecessary animal testing, and the conditions for … ca d\u0027zan mansionWebKai is a Chartered Biologist (RSB) and currently works as a Senior Consultant for Blue Frog Scientific focusing on regulatory affairs and risk assessment in the EU (responsibilities: nanoparticle/ nanomaterial, study monitoring, ecotoxicology, toxicology, statistical analysis, DGA, dossier prep., literature rev., read-across and in silico … ca d\u0027zan sarasotacaduceus snakeWebRead-across assessment framework (RAAF, March 2024)5 RAAF - considerations on multi-constituent substances and UVCBs (RAAF UVCB, March 2024)6 Physical-chemical properties Guidance on information requirements and chemical safety assessment, Chapter R.7a (version 6.0, July 2024), referred to as ECHA Guidance R.7a in this decision. … ca d\u0027zan photosWebEuropean Commission and MS to discuss and exchange views on ECHA’s Read-Across Assessment Framework (RAAF), which is still under development. The RAAF is a tiered systematic approach, developed by ECHA to facilitate its internal evaluation of read-across. The second day, organised with the active support of Cefic LRI, aimed to bring ca d\u0027zan toursWebIn contrast, the broad availability of toxicity data for industrial chemicals has triggered regulatory frameworks for read-across (e.g. ECHA Read-Across Assessment Framework), software tools and public databases for an automated process of gap filling in the context of safety assessment. caduff sa tavanasa