Higuchi and connors

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August undefined, 2024

WebIn a famous publication by Higuchi and Connors, complexes were classified based on the phase solubility profiles derived from the molecular interactions between the host and the … WebJan 11, 2024 · The shake-flask method proposed by Higuchi and Connors is widely used in the determination of a drug’s solubility. It determines the thermodynamic solubility of the drug after reaching equilibrium.

Higuchi and Connors, "Spectrophotometric Detection of the End …

WebIt is a blood scihozonticide and active against all stages of Plasmodium falciparum. The drug is also used for the treatment of cerebral malaria as well as for the chloro- quine resistant cases [2-5]. Unfortunately, it is water- insoluble (17 µg/ml at room temperature) [6] and the formulation causes difficulties to the biopharmaceutical scientist. WebT. Higuchi and K. A. Connors, “Phase-Solubility Techniques,” In: C. N. Reilly, Ed., Advances in Analytical Chemistry and Instrumentation, Wiley-Interscience, New York, Vol. 4, 1965, pp. … novant health pulmonology wilmington nc

Solubility enhancement and application of cyclodextrins in

WebMar 28, 2014 · Solubility studies were performed according to the method reported by Higuchi and Connors and the phase solubility diagrams were plotted. The repaglinide-nanosponges complexes were prepared, lyophilized and the resulted inclusion complexes were characterized by FT-IR and NMR. WebAug 8, 2024 · The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ( [H 4 MGF] = f ( [βCD])) of saturated solutions in mangiferin must show a linear trend and then equation ( 6) relates the slope ( α) and intercept ( G0) of the straight line with the equilibrium … novant health radiation oncology forsyth

T. Higuchi and K. A. Connors, “Phase-Solubility Tech-niques,” …

Higuchi and Connors, "Phase-Solubility Techniques,", 1964 ...

WebPersonal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library. Higuchi and Connors, "Spectrophotometric Detection of the End Point in the Karl Fischer Titration of Water,", 1959, Box: 11, Folder: 110. Personal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library. WebJan 30, 2024 · According to Higuchi and Connors (1965), the linear host-guest correlation can be classified as linear diagram (A L) type because the straight line had a slope of less than 1 in each compound, i.e., 0.0074, 0.0202 and 0.0266 for curcumin, demethoxycurcumin, and bisdemethoxycurcumin, respectively. The result indicated that one mole of ... how to smoke beef short ribs on gas grillWebMay 1, 1999 · There are many methods for determination of stability constants of CyD complexes, using techniques such as solubility (Higuchi and Connors, 1965), … how to smoke beef ribeye boneless roast

"WebDec 18, 2024 · Phase solubility test was performed according to the method of Higuchi and Connors [ 24 ]. An excess amount of camphor was added to aqueous CD (HPβCD and HPγCD) solutions, and the suspensions were shaken at RT. After equilibrium was achieved at the end of 48 h, the suspensions were filtered with 0.45 μm membrane filter. " - Higuchi and connors

Higuchi and connors

Phase solubility diagrams and their classification according to Higuchi …

WebSolubility profiles by Higuchi and Connors theory. So is the drug intrinsic solubility in cyclodextrin absence 76 . Source publication Alternative Technologies to Improve … WebMar 22, 2024 · We also introduced the Higuchi and Connors method to analyze inclusion complex formed through solubilization and the pharmaceutical benefits that can be gained using CDs. In addition, the practical applications of CDs in nasal, ophthalmic, pulmonary, and rectal drug delivery are also described. CD applications for drug solubilization

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WebJan 1, 2011 · T. Higuchi, K.A. Connors. Phase solubility techniques. Adv Anal Chem Instrum, 4 (1965), pp. 117-212. Google Scholar [18] L. Greenspan. Humidity Fixed Points of Binary Saturated Aqueous Solutions. J Res Nat Bur Stand, 81A (1) (1977), pp. 89-96. CrossRef Google Scholar [19] WebTypes of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are …

WebMay 1, 1999 · There are many methods for determination of stability constants of CyD complexes, using techniques such as solubility ( Higuchi and Connors, 1965 ), potentiometry ( Miyaji et al., 1976 ), high-pressure liquid chromatography ( Uekama et al., 1978 ), and kinetic ( Bender and Komiyama, 1978) and spectroscopic ( Cramer et al., 1967, Thakkar et … WebFeb 27, 2010 · According to Higuchi and Connors there can be five types of phase-solubility relationship (Fig. 1): A L-type where there is a linear relationship between substrate (drug) …

WebT. Higuchi, A. Connors Published 1965 Chemistry No Paper Link Available Save to Library Create Alert Cite 2,633 Citations Citation Type More Filters Development of Solvent-Free … WebPhase-solubility studies Water solubility studies for both triterpenic acids were conducted by the Higuchi and Connors method [16] using a series of increasing concentrations of …

Webevaluated by the methods described by Higuchi and Connors.20) Twenty mL of 0.007–0.252M CD aqueous solution in a glass beaker was placed in a 25 C water bath. Excess ALA was added to the CD solution and the mixture was homogenized at 2,000rpm with a T. K. ROBO MICS (Primix, Osaka, Japan). The suspension was ﬁltered

WebJan 15, 2024 · Phase-solubility profiles and classification of drug/cyclodextrin complexes according to Higuchi and Connors (Higuchi and Connors, 1965). The phase solubility … how to smoke beef short ribsWebThe present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability. Finally increase the half life of the ... how to smoke bhoWebThe most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that … how to smoke beef short ribs w/boneWebThis was explained by the solubilization theory of Higuchi and Connors. The solubility analysis of the ternary drug/competitor/CyD systems may be particularly useful for … novant health raleighWebMay 9, 2007 · A phase solubility study was performed, according to the method reported by Higuchi and Connors, to evaluate the changes of isoflavone in the complexation state and the obtained diagrams suggested that it forms complexes with a stoichiometry of 1:1. how to smoke beef sirloin tip roastWebSep 1, 2010 · The phase-solubility diagrams obtained according to the Higuchi and Connors method [6] allowed us to estimate the molar ratio and the apparent stability constants of … how to smoke beef tallowWebT. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: … how to smoke beef sticks