WebOTUB1 possesses a non-canonical, catalytic-independent activity where it inhibits the transfer of ubiquitin onto protein substrates by binding to the ubiquitin-charged E2. This review will describe the canonical and non-canonical activities of OTUB1, summarize OTUB1’s regulation of cancer-associated pathways and discuss OTUB1’s potential WebNM1 Ø45 AC Manual Override Wired Tubular Motor, TUBE brand is owned and developed by Zhejiang LianDa Science & Technology Co.,Ldt., wholly owned company by the …
Non-canonical inhibition of DNA damage-dependent …
WebMar 3, 2012 · OTUB1 N-terminal arm and the mechanism of E2 inhibition. ... Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell. 1999; 96:645–653. [Google Scholar] 11. Yin L, Krantz B, Russell NS, Deshpande S, Wilkinson KD. Nonhydrolyzable diubiquitin analogues are inhibitors of ... WebJun 22, 2024 · OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation Cell Death Dis. 2024 Jun 22;13 (6):560. … imbiss ottmarsbocholt
Molecular Studies of Noncanonical NF-kb Signaling
WebAug 4, 2024 · Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield Authors: Wang Shuansuo Chinese Academy... WebJan 27, 2015 · OTUB1 mediates prostate cancer cell invasion through RhoA activation and promotes tumorigenesis in vivo. Our results suggest that drugs targeting the catalytic activity of OTUB1 could potentially be used as therapeutics for … WebJan 1, 2024 · Otubain-1 (OTUB1) protease is identified as a novel amplifier of the proto-oncogene c-MYC, a critical cancer driver that correlates with inferior clinical outcomes in the c- MYC-dependent cancer multiple myeloma, and overexpression of OTUB1 accelerates the growth of myel cancer cells. 3 PDF list of it companies in dubai