Web6WTF: Structure of radical S-adenosylmethionine methyltransferase, TsrM, from Kitasatospora setae with tryptophan substrate and SAM analog (aza-SAM) bound. PDB ID: 6WTF Download: MMDB ID: 196743: PDB Deposition Date: 2024/5/2: Updated in MMDB: 2024/01: Experimental Method: WebHerein, we report structures of TsrM from Kitasatospora setae, which are the first structures of a cobalamin-dependent radical SAM methylase. Unexpectedly, the structures show an …
Crystallographic snapshots of TsrM, a cobalamin-dependent …
WebThe Cbl-dependent radical SAM enzymes OxsB, TsrM, and TokK showcase similar architectures that capitalize on the traditional Cbl-binding and radical SAM domains. … WebFeb 2, 2024 · The radical SAM [4Fe–4S] cluster 28,29,30,31 is coordinated by three cysteine residues (C15, C19 and C22) and, in contrast to all known radical SAM enzymes, by a … dr mines watson clinic
6WTF: Structure of radical S-adenosylmethionine methyltransferase, TsrM …
WebAbout Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features Press Copyright Contact us Creators ... WebSep 1, 2024 · TsrM catalyzes the methylation of C2 in l-tryptophan (Trp). This reaction is the first step in the biosynthesis of the quinaldic acid moiety of the thiopeptide antibiotic thiostrepton, which exhibits potent activity against Gram-positive pathogens. TsrM is a member of the radical S -adenosylmethionine (SAM) superfamily of enzymes, but it does … http://biblioteka.muszyna.pl/mfiles/abdelaziz.php?q=l-sam coldwell banker loans